The physiological magnetic resonance techniques of diffusion
imaging, perfusion imaging and spectroscopy offer insights into brain
structure, function and metabolism. Until recently, they were mainly
applied within the realm of medical research, but with their increasing
availability on clinical MRI machines, they are now coming into
clinical practice for the evaluation of neuropathology in individual
patients. This book provides the reader with a thorough review of the
underlying physical principles of each of these methods, as well as
comprehensive coverage of their clinical applications. Topics covered
include single- and multiple-voxel MRS techniques, MR perfusion based
on both arterial spin labelling and dynamic bolus tracking approaches,
and diffusion-weighted imaging, including techniques for mapping brain
white matter fiber bundles. Clinical applications are reviewed in depth
for each technique, with case reports included throughout the book.
Attention is also drawn to possible artifacts and pitfalls associated
with these techniques.
Table of contents:
Foreword Jonathan Gillard, Adam Waldman and Peter Barker; Introduction
Nick Bryan; 1. Fundamentals of MR spectroscopy Peter Barker; 2.
Quantification and analysis in MR spectroscopy Thomas Ernst; 3.
Artifacts and pitfalls in MR spectroscopy Ralph Hurd; 4. Fundamentals
of diffusion MR imaging Derek Jones; 5. MR tractography using diffusion
tensor MR imaging Susumu Mori and Peter van Zijl; 6. Artifacts and
pitfalls in diffusion MR imaging Martin Koch and David Norris; 7.
Cerebral perfusion imaging by exogenous contrast agents Leif
Ostergaard; 8. MRI detection of regional blood flow using arterial spin
labeling Alan Koretsky, Lalith Talagala, Shella Keilholz and Afonso
Silva; 9. Artifacts and pitfalls in perfusion MR imaging Fernando
Calamante; 10. Cerebrovascular disease - overview Brian Tress; 11. MR
spectroscopy in stroke Peter Barker and Jonathan Gillard; 12. Diffusion
and perfusion MR in stroke Joanna Wardlaw; 13. Arterial spin labeling
in stroke John Detre and Jyongjiong Wang; 14. Magnetic resonance
diffusion tensor imaging in stroke Pamela Schaefer, Luca Roccatagliata
and Gilberto Gonzalez; 15. MR spectroscopy in severe obstructive
carotid artery disease Jeroen van der Grond and Dirk Rutgers; 16.
Perfusion and diffusion imaging in chronic carotid disease Iain
Wilkinson; 17. Imaging migraine pathogenesis Mike Welch; 18. Adult
neoplasia: overview Tom Mikkelsen; 19. MR spectroscopy of brain tumors
in adults Jeffry Alger; 20. Diffusion MR imaging in adult neoplasia
Brian Ross, Brad Moffat and Thomas Chenevert; 21. Perfusion MR imaging
in adult neoplasia Alan Jackson; 22. Physiological imaging in
infection, inflammation and demyelination: overview Robert Zimmerman;
23. MR spectroscopy in intracranial infection Rakesh Gupta and Monika
Garg; 24. The role of diffusion-weighted imaging in intracranial
infection Christopher Fillipi; 25. MR spectroscopy in demyelination and
inflammation Gioacchino Tedeschi and Simona Bonavita; 26. Diffusion
imaging in demyelination and inflammation Massimo Filippi and Marco
Rovaris; 27. Physiological MR to evaluate HIV-associated brain
disorders Linda Chang and Thomas Ernst; 28. Seizure disorders: overview
Thomas Henry; 29. MR spectroscopy in seizure disorders Graeme Jackson,
Regula Brielmann and Mark Wellard; 30. Diffusion and perfusion MR
imaging in seizure disorders Konstantinos Arfanakis and Bruce Hermann;
31. Psychiatric and neurodegenerative disease: overview Adam Waldman;
32. MR spectroscopy in psychiatry John Port; 33. Diffusion MR imaging
in psychiatry and aging Adolf Pfefferbaum, Edith Sullivan and Elfar
Adalsteinsson; 34. MR spectroscopy in aging and dementia Clifford Jack
and Kejal Kantarci; 35. MR spectroscopy in neurodegeneration Charles
Davie; 36. Potential role of MR spectroscopy, diffusion
weighted/diffusion tensor imaging and perfusion weighted imaging in
traumatic brain injury: overview John Pickard; 37. MR spectroscopy in
traumatic brain injury William Brooks; 38. Diffusion- and
perfusion-weighted MR imaging in head injury David Menon and Peter
Bradley; 39. Physiological MR of the pediatric brain: overview Elias
Melhem and Xavier Golay; 40. Physiological MRI of normal development
and developmental delay A. James Barkovich, Dan Vigneron and Pratik
Mukherjee; 41. MR spectroscopy of hypoxic brain injury Brian Ross,
Cathleen Enriquez and Alexander Lin; 42. The role of diffusion and
perfusion weighted brain imaging in neonatology Mary Rutherford; 43.
Physiological MR of pediatric brain tumors Jill Hunter; 44.
Physiological MRI techniques and pediatric stroke W. Kling Chong, V.
Cionini and Dawn Saunders; 45. MR spectroscopy in pediatric white
matter disease Folker Hanefeld, Knut Brockman and Peter Dechent; 46. MR
spectroscopy of inborn errors of metabolism Alberto Bizzi, Marianna
Bugiani and Ugo Danesi.
This book is indeed a welcomed addition to the
rapidly growing knowledge base of clinical neuroimaging, as it will
undoubtedly provide medical professionals with a clear and informative
reference to emerging state-of-the-art neuroimaging applications.
Clinical MR Neuroimaging: Diffusion, Perfusion and Spectroscopy by J.
Gillard et al. is a wonderful reference book for physicians and
radiologists looking for comprehensive coverage of clinical
applications, as well as for biomedical engineers, MR physicists, and
other more interested in the underlying physical principles of these
novel MR techniques." Health Physics, Dardo Tomasi
"This is a long overdue text that clarifies and simplifies the application of
contemporary MR diffusion imaging (especially diffusion tensor imaging and
white matter tractography), MR perfusion imaging and MR spectroscopy. Its
greatest value is its comprehensive treatment of the theory of these imaging
methods without resorting to advanced mathematical descriptions that would be
beyond the level of many practicing physicians. I have not seen a comparable
text on the market."--Doody's Review ServiceŽ
physiologic and functional MR techniques described in this book are
here to stay and already used in the field, beyond academic sites. The
editors achieve their goal of providing detailed reference tutorials
for neuroimagers to understand current uses. This book is worth the
cost as a reference for those who do neuroimaging or refer patients for
neuroimaging studies." - Radiology, Allan J. Fox, MD