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 Clinical
The Cancer Degradome 
Proteases and Cancer Biology 
Edited by: Edwards, D.; Hoyer-Hansen, G.; Blasi, F.; Sloane, B.F. 
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Description:

Proteases that act in the extracellular environment have been historically associated with tumorigenesis and metastasis by virtue of their ability to carry out "path-clearing" for cancer cells. In the past few years it has become clear that they also shape the pericellular signaling environment, with profound consequences for cell fate and phenotype in both normal development and disease states. The repertoire of proteases that cells and tissues coordinately regulate in order to modulate their local environment is the DEGRADOME – which in humans is represented by at least 569 proteases in five catalytic classes. "The Cancer Degradome: Proteases in Cancer Biology" , edited by Dylan Edwards, Francesco Blasi, Gunilla-Høyer-Hansen and Bonnie Sloane, covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how protease activity can be imaged both in vitro and in vivo; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; the links that have emerged between proteolysis and cell signaling; how the Degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to target proteolysis for therapy.


Written for:

Researchers in cancer proteases, basic cancer researchers, oncologists, those working in the areas of bioinformatics, proteomics, cancer chemistry, drug development

Table of contents:

Section 1: The Degradome and its analysis

Chapter 1: Protease Genomics and the Cancer Degradome

Xose S. Puente, Gonzalo R Ordonez & Carlos López-Otín

Chapter 2: The CLIP-CHIP: A focused oligonucleotide microarray platform for transcriptone analysis for the complete human and murine cancer degradomes.

Rheinhild Kappelhoff, Claire H.Wilson, & Christopher M. Overall

Chapter 3: The Hu/Mu ProtIn chip: A custom dual-species Oligonucleotide Microarray for profiling degradome gene expression in tumours and their microenvironment

Donald R.Scwartz, Kamiar Moin, Ekkehard Weber & Bonnie F Sloane

Chapter 4: Quantitative Real-Time PCR analysis of degradome gene expression

Caroline J Pennington, Robert K. Nuttall, Clara Sampieri -Ramirez, , Matthew Wallard, Simon Pilgrim & Dylan R. Edwards

Chapter 5: Identification of protease substrates by mass spectrometry approaches.

Mari Enoksson,Wenhong Zhu & Guy Salvesen

Chapter 6: Identification of protease substrates by mass spectrometry approaches – 2.

Anna Prudova, Ulrich auf dem Keller & Christopher M. Overall

Chapter 7: Activity based imaging and biochemical profiling tools for analysis of the cancer degradome.

Vincent Dive, Margot Paulick, J.Oliver McIntyre, Lynn M. Matrisan & Matthew Bogyo.

Chapter 8: Images of cleavage

Kamiar Moin,Mansoureh Sameni, Christopher Jedeszko, Quanwen Li, Mary B. Olive, Raymond R. Mattingly & Bonnie F. Sloane

Section 2: Insights into Protease function

Chapter 9: Proteolytic pathways: Intersecting cascades in cancer development

Nesrine I. Affara & Lisa M, Coussens

Chapter 10: Physiological functions of plasminogen activation: Effects of gene deficiences in humans and mice

Thomas H. Bugge

Chapter 11: The plasminogen activation system in tissue remodelling and cancer invasion

Kasper Almholt, Anna Juncker-Jensen, Kirsty Anne Green, Helene Solberg, Leif Roge Lund & John Rømer

Chapter 12: The urokinase plasminogen activator receptor as a target for cancer therapy

Silvia D’Alessio & Francesco Blasi

Chapter 13: The endocytic collagen receptor uPARAP/Endo 180 in cancer invasion and tissue remodelling

Thore Hillig, Lars H. Engelholm & Niels Behrendt

Chapter 14: Physiological and pathological functions of type II transmembrane serine proteinases:Lessons from transgenic mouse models and human disease-associated mutations.

Karin List & Thomas Bugge

Chapter 15: Analysis of cysteine cathepsin knockout mice in cancer models

Thomas Reinheckel, Vasilena Gocheva, Christoph Peters & Johanna A. Joyce

Chapter 16: In vitro and in vivo models of angiogenesis to dissect MMP functions.

Sarah Berndt, Françoise Bruyère, Maud Jost & Agnès Noël

Chapter 17: The surface transplantation model to study the tumour-host interface

Maud Jost, Silvia Vosseler, Silvia Blacher, Norbert E. Fusenig, Margareta Mueller & Agnes Noel

Chapter 18: Unravelling the roles of proteases in cell migration in vitro and in vivo

Jelena Gavrilovic & Xanthe Scott

Chapter 19: New insights into MMP function in adipogenesis

Kumari L Andarawewal & Marie-Christine Riol

Chapter 20: TIMPs:Extracellular Modifiers in Cancer Development

Aditya Murty,William Cruz-Munoz & Rama Khokha

Section 3: The interface between Proteolysis and Cell Signalling

Chapter 21: Invadopodia: Interface for Invasion

Susette C Mueller, Vira V. Artym & Thomas Kelly

Chapter 22: uPAR and proteases in mobilization of hematopoietic stem cells

Pia Ragno & Francesco Blasi

Chapter 23: The urokinase receptor (uPAR) and integrins constitute a cell migration signalosome

Bernard Degryse

Chapter 24: Measuring uPAR dynamics in live cells

Moreno Zamai, Gabriele Malengo & Valeria R. Caiolfa

Chapter 25: Janus-faced effects of broad-spectrum and specific MMP inhibition on metastasis

Charlotte Kopitz & Achim Kruger

Chapter 26: Cytokine Substrates: MMP regulation of inflammatory signalling molecules

Jennifer H. Cox & Christopher M. Overall

Chapter 27: Matrix metalloproteinases as key regulators of tumour:bone interaction

Conor C. Lynch & Lynn M. Matrisan

Section 4: The degradome as source of cancer diagnostic and prognostic markers

Chapter 28: The plasminogen activation system as a source of prognostic markers in cancer

Ib Jarle Christensen, Helle Pappot & Gunilla Hoyer-Hansen

Chapter 29: Cysteine cathepsins and cystatins as cancer biomarkers

Tamara T. Lah, Natasa Obermaja, Maria Beatriz Duran Alonso & Janko Kos

Chapter 30: Novel degradome markers in breast cancer

Caroline J. Pennington, Simon Pilgrim, Paul N Span Fred C. Sweep & Dylan R. Edwards

Chapter 31: Meta-analysis of gene expression microarray data: Degradome genes in healthy and cancer tissues

Kristiina Iljin, Sami Kilpinen, Johanna Ivaska & Olli Kallioniemi

Chapter 32: Degradome gene polymorphisms

Ross Laxton & Shu Ye

Chapter 33: TIMP-1 as a prognostic marker in colorectal cancer

Camilla Frederiksen, Anne Fog Lomholt,Hans Jorgen Nielsen & Nils Brunner

Section 5: Novel therapeutic strategies

Chapter 34: Structure and inhibition of the urokinase-type plasminiogen activator receptor (uPAR)

Benedikte Jacobsen, Magnus Kjaergaard, Henrik Gardsvoll & Michael Ploug

Chapter 35: Engineered antagonists of uPA and PAI-1

M. Patrizia Stoppelli, Lisbeth M, Andersen, Giuseppina Votta & Peter A. Andreasen

Chapter 36: MMP inhibitor clinical trials – the past present and future

Barbara Fingleton

Chapter 37: Tailoring TIMPs for selective metalloproteinase inhibition

Hideaki Nagase & Gillian Murphy

Chapter 38: Third Generation MMP Inhibitors: Recent advances in the development of highly selective inhibitors

Athanasios Yiotakis & Vincent Dive

Chapter 39: Protease activated delivery and Imaging systems

Gregg Fields

Chapter 40: Development of tumour selective and endoprotease-activated anticancer therapeutics

Jason H. Gill & Paul M. Loadman

Chapter 41: Targeting Degradome genes via engineered Viral Vectors

Risto Ala-aho, Andrew H. Baker & Veli-Matti Kahari


Edited by: Edwards, D.; Hoyer-Hansen, G.; Blasi, F.; Sloane, B.F.
926 Pages, Illustrations: 90 illus., 33 in color. With 2 16-page inserts., H, 2009
$159.00 U.S.
ISBN: 978-0-387-69056-8 ; Springer-Verlag  
email: info@advmedpub.net
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