Well into its second decade of existence, RABEX continues to be a unique and important educational tool for the certification and continuous education of residents and senior radiation oncologists. The present edition of RABEX follows the original goals defined in the 1990’s by Drs. J. D. Chapman, S. Shahabi, L. R. Coia and B. Corn. However, due to the increase in knowledge in the field of biology and the rapid development of electronic distribution of information, RABEX needed to be updated to match these challenges. The ultimate goal of the present edition is to maintain its level of excellence with relevant updates in topics and contents.

     The topics included in the RABEX practice examination continue to be based upon those listed by the American Board of Radiology for the cognitive exam in radiation and cancer biology. Also, the number of questions in each section reflects the ABR's relative weight for each topic. Therefore, this practice examination provides guidance for residents and senior radiation oncologists in their preparation for the initial radiation oncology certification examination as well as to demonstrate cognitive expertise in radiation biology required for maintenance of certification.

     The exam consists of 200 multiple choice questions in, ABR format:
Molecular mechanisms of DNA damage and repair; chromosome and chromatid damage; mechanisms of cell death; cell survival models; LET and RBE; oxygen effect; repair at the cellular level; tumor microenvironment; cell and tissue kinetics; molecular signaling; cancer biology; total body irradiation; clinical and mechanistic responses to radiation of normal tissues; therapeutic ratio; time, dose and fractionation; brachytherapy; alternative radiation modalities; chemotherapeutic agents; radiosensitizers, bioreductive drugs and radioprotectors; hyperthermia; radiation carcinogenesis; heritable effects of radiation; radiation effects in the developing embryo; radiation protection, Radiologic Terrorism, & Molecular Imaging.

      The answer, along with an explanation and appropriate reference, will be provided for each question.

Editor-in- Chief:
Marcelo Vazquez, MD, PhD
Loma Linda University, Radiation Medicine
MVazquez@llu.edu

Chief- Technical Editor:
Siamak Shahabi, PhD
Rabex Organization & Advanced Medical Publishing, Inc.
info@rabex.net

Marcelo Vazquez, PhD, Lead, Clinical Translational Radiobiology Research  Dept. of Radiation Medicine  Loma Linda University Medical Center, CA, Gary Y. Yang, MD, Editor-in- Chief, Journal of Gastrointestinal Oncology (JGO), President, Society for Gastrointestinal Oncology (SGO), Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, CA, Omar Y. Mian, MD, PhD,  Department of Translational Hematology & Oncology Research (THOR) | Department of Radiation Oncology |  Cleveland Clinic, Cleveland, OH,   Kathryn Huber, MD, PhD , Radiation Oncology, Director, Department of Radiation Oncology, Radiation Oncology Training Program, Tufts Medical Center, Boston, MA, Erica Bell, PhD, Radiation Oncology, Director, Department of Radiation Oncology, Radiation Oncology Training Program, Ohio State University, Columbus, OH,  Jessica Fleming, PhD, Radiation Oncology, Director, Department of Radiation Oncology, Radiation Oncology Training Program, Ohio State University, Columbus, OH, Mark Ritter, MD, University of Wisconsin, Department of Radiation Oncology, Madison, WI, Minesh Metha, MD, Deputy director and chief of Radiation Oncology at Miami Cancer Institute at Baptist Health South Florida, Richar Miller, PhD, University of Chicago, Chicago, Cell Biology, Cancer Research, Accelerator Physics, & Siamak Shahabi, PhD, Chief-Technical Editor,  Rabex Organization & Advanced Medical Publishing, Inc., and Cancer-Matrix Manual, USA.