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  RABEX Online Exams: The Radiation and Cancer Biology Practice Examination

                                                                 New  Rabex 2024
                                                                   Try RABEX Demo Exam 
     Sign-up to take the RABEX Demo, a free sample exam with one question per category for a total of 31 questions. The RABEX Demo follows the ABR Guidelines for "Radiation & Cancer Biology" syllabus, exact table of content and it is similar in questions and format to the full exam which is 200 questions and 200 minutes long. Institution and individual should download the form below to register for full exam.  

1. Institutions can download RABEX 2024 Registration Form and email to   --> info@Rabex.net
2. Individuals can enroll for the Full Exam and pay via credit card by click here.

A. Click here to view: RABEX Table of Contents Future & History

     The purpose of RABEX: The "Radiation and Cancer Biology Practice Examination" is to supplement the training of radiation oncology residents by providing an educational resource to help guide residents in the study of Radiation and Cancer Biology. It is anticipated that the Radiation and Cancer Biology Practice Examination will also assist residents and board eligible radiation oncologists in preparation for the  Radiation and Cancer  Biology section of the cognitive exam administered by the American Board of Radiology (ABR) for certification in Radiation Oncology. 

    Well into its second decade of existence, RABEX continues to be a unique and important educational tool for the certification and continuous education of residents and senior radiation oncologists. The present edition of RABEX follows the original goals defined in the 1990's by Drs. J. D. Chapman, S. Shahabi, L. R. Coia and B. Corn. However, due to the increase in knowledge in the field of biology and the rapid development of electronic distribution of information, RABEX needed to be updated to match these challenges. The ultimate goal of the present edition is to maintain its level of excellence with relevant updates in topics and contents. 
    The topics included in RABEX practice examination continue to be based upon those listed by the American Board of Radiology for the cognitive exam in radiation and cancer biology. Also, the number of questions in each section reflects the ABR's relative weight for each topic. Therefore, this practice examination provides guidance for residents and senior radiation oncologists in their preparation for the initial radiation oncology certification examination as well as to demonstrate cognitive expertise in radiation biology required for maintenance of certification. 

     The exam consists of 200 multiple choice questions innewly updated ABR Guidelines:

I. Interaction of radiation with mattera. Definition of ionizing radiation, free radicals, and radical damage, 
     b. Direct and indirect action of radiation, numbers and types of DNA lesions, 
     c. Consequences of unrepaired DNA DSB

II. Molecular and cellular damage and repaira. Molecular mechanisms of DNA damage, 
                                                                         b. Molecular mechanisms of DNA repair, 
c. Cellular recovery, 
                                                                         d. Chromosome and chromatid damage

III. Cellular responses to radiationa. Mechanisms of cell death, b. Cell and tissue survival assays: measurement of response, 
                                                        c. Models of cell survival

IV. Linear energy transfer (LET) and oxygen effecta. Linear energy transfer, b. Oxygen Effect

V. Tumor biology and microenvironmenta. Solid tumor assay systems, b. Tumor microenvironment

VI. Cancer biology, a. Cell and tissue kinetics, b. Molecular signaling, c. Mechanisms of cancer development, 
                                d. Cancer genetics/genomics

VII. Radiobiology of normal tissuesa. Clinically relevant normal tissue responses to radiation, b. Mechanisms of normal tissue 
                                                              radiation responses, c. Total body irradiation

VIII. Dose delivery
aTherapeutic ratio, b. Time, dose, and fractionation, c. Brachytherapy, d. Radiobiological aspects 
                                    of different radiation modalities 

IX. Combined modality therapya. Chemotherapeutic agents and radiation therapy, b. Radiosensitizers, bioreductive drugs, 
                                                        and radioprotectors, c. Immune therapeutics, d. Hyperthermia

X. Late effects and radiation protectiona. Radiation carcinogenesis, b. Heritable effects of radiation, c. Radiation effects in the 
                                                                    developing embryo, d. Radiation protection
      The answer, along with an explanation and appropriate references, will be provided for each question. 

Marcelo Vazquez, MD, PhD
Loma Linda University, Radiation Medicine

Chief-Technical Editor:
Siamak Shahabi, PhD 
Rabex Organization & Advanced Medical Publishing, Inc.


Marcelo Vazquez, MD, PhD, Lead, Clinical Translational Radiobiology Research  Dept. of Radiation Medicine  Loma Linda University Medical Center, CA, Alejandro Carabe-Fernandez, PhD, Department of Radiation Oncology, The Hospital of the University of Pennsylvania, Philadelphia, PA, Erica Bell, PhD, Department of Radiation Oncology, Associate professor, Radiation Biology Director, The Ohio State University, Columbus, OH, Manuela Buonanno, PhD, Columbia UniversityCenter for Radiological Research, NY,  Veljko Grilj, PhD, RARAF Laboratories, Columbia University, NY, Jessica Fleming, PhD Department of Radiation Oncology at the Ohio State University, Columbus, OH, Antonella Bertucci, PhD, Associate Researcher, Loma Linda University, Department of Radiation Medicine Siamak Shahabi, PhDChief-Technical Editor, Rabex Organization & Advanced Medical Publishing, Inc., and Cancer-Matrix Manual, USA.

Past Contributors: 1995-present
J. D. Chapman, PhDEditor-in-Chief

Associate Editors:

Gary Y. Yang, Kathryn Huber, MD, PhD, Mark Ritter, MD, PhD, Richard Miller, phD, Minesh Mehta, MD, Joan Allalunis-Turner, PhD, Paul C. Billings, PhD, David A. Boothman, PhD, J. Martin Brown, PhD, Lawrence R. Coia, MD, William C. Dewey, PhD, Evan B. Douple, PhD, Richard P. Hill, PhD, Clifton C. Ling, PhD, Luka Milas, PhD, William F. Morgan, PhD., Colin G. Orton, PhD, Mark A. Ritter, MD, PhD, Sara Rockwell, Barry S. Rosenstein, PhD, Joseph L. Roti Roti, PhD, Craig W. Stevens, MD, Beverly A. Teicher, PhD, E. Day Werts, PhD, & H. Rodney Withers, PhD.

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