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 Clinical
Targeted Radionuclide Therapy 
 
Tod W Speer MD 
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Description:

Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion.

Table of Contents:

Part I: IMMUNOLOGY AND TARGETING CONSTRUCTS

1: The Immune System

2: Methods for Development of Monoclonal Antibody Therapeutics

3: Peptides

4: Affibody Molecules for Targeted Radionuclide Therapy

5: Aptamers

Part II: PHYSICS AND RADIOBIOLOGY OF TRT

6: The Physics and Radiobiology of TRT

7: Chelation Chemistry

8: Radiation Dosimetry

9: Microdosimetry

10: Radiation Safety for RT

Part III: TUMOR MICROENVIRONMENT AND DELIVERY STRATEGIES

11: Employing SEREX

12: Antibody Penetration into Tumors

13: Overcoming Barriers Posed by Solid Tumors

14: The Delivery Construct

15: The Type of Radionuclide

16: Pretargeting Strategies for TRT

17: Combined Modality Strategies

18: Extracorporeal Techniques

19: Concept of Systemic Therapy

20: Modeling of the Systemic Cure with TRT

Part IV: UNCONJUGATED THERAPY

21: Thyroid Cancer

22: Unconjugated Radiopharmaceuticals

23: 90-y Microspheres

24: SIRT

Part V: CONJUGATED THERAPY

25: Colorectal Cancer

26: Pancreatic Cancer

27: Hepatobillary Cancer

28: Astrocytoma

29: Medullary Thyroid Cancer

30: Head and Neck Cancer

31: Prostate Cancer

32: Renal Cell Carcinoma

33: Bladder Cancer

34: Leukemia

35: Non-Hodgkin's Lymphoma

36: Hodgkin's Disease

37: Multiple Myeloma

38: Neuroendocrine Tumors

39: Malignancies Treated with Peptides

40: Ovarian Cancer

41: Osteosarcoma

42: Pediatric Tumors

43: Palliation

44: Melanoma



Tod W Speer MD
608 Pages, Illustrations: 110, November 2010
$179.00 U.S.
ISBN: 0-7817-9693-8; ISBN-13: 978-0-7817-9693-4  
email: info@advmedpub.net
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Radiation Oncology (Clinical)

Clinical Oncology

   Essential textbooks
IGRT
   Neurosurgery
   Prostate
   Lung
Special Topics
   Breast
   CNS
   Endocrine
   Head & Neck
   Gynecological
   Gastrointestinal
   Genitourinary
   Leukemias & Lymphomas
   Lung
   Neuro-Oncology
   Ophthalmic-Oncology
   Pediatric
   Prostate
    Skeletal
   Skin
Staging
   AJCC
   Color-matrix staging
   Staging atlas
   TNM classification
Surgical Oncology
Treatment Planning
   Basic treatment planning
   3-D conformal therapy
   3-D conformal & IMRT
   Intensity modulated RT (IMRT)
   CT-simulation
Physics
   Basic & clinical
Brachytherapy
   General
   Intra-vascular
   High-dose rate
   Low-dose rate
   Pediatric
   Quality assurance
Special procedure
   Intraoperative
   Stereotactic radiosurgery
   Neutron capture therapy
   Hyperthermia
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Oncologic Nursing
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