Exam
opens on June 1,
2019
Table of
contents,
Rabex future, & history
, Email to ----->
info@Rabex.net
The
purpose of
RABEX:
The
Radiation and Cancer
Biology Practice Examination is to supplement the
training
of radiation oncology residents by providing an
educational resource to help guide residents in the study of cancer
and radiation
biology. It is anticipated that the Radiation and Cancer Biology
Practice
Examination will also assist residents and board eligible radiation
oncologists in preparation for the
Radiation and Cancer
Biology section of
the cognitive
exam
administered by the
American Board of
Radiology
(ABR)
for certification in radiation oncology.
Well into its second
decade of existence, RABEX continues to be a unique and
important educational
tool for the certification and continuous education of residents and
senior radiation oncologists. The
present edition of RABEX follows
the original goals defined in
the 1990's by Drs. J. D. Chapman, S.
Shahabi, L. R. Coia and B. Corn. However, due to the
increase in knowledge in the field of biology and
the rapid development of electronic distribution of information,
RABEX needed to
be updated to match
these challenges. The ultimate goal of the present edition is to
maintain its level of excellence with
relevant updates in topics and contents.
The topics included in the
RABEX practice
examination continue to be
based upon those listed by
the American Board of Radiology for the cognitive
exam in
radiation
and cancer biology. Also, the number
of questions in each section reflects the ABR's relative weight for
each topic. Therefore, this practice
examination provides guidance for residents and senior radiation
oncologists in their preparation for
the initial radiation oncology certification examination as well as to
demonstrate cognitive expertise in
radiation biology required for maintenance of certification.
The exam consists
of 200 multiple choice questions in, newly updated ABR
Guidelines:
I. Interaction of
radiation with matter,
a. Definition of
ionizing radiation, free radicals, and radical damage, b. Direct and indirect action
of radiation,
numbers and
types of DNA lesions, c. Consequences of unrepaired DNA DSB
II. Molecular and
cellular damage and repair, a. Molecular
mechanisms of DNA damage, b. Molecular mechanisms of DNA repair, c. Cellular recovery,
d.
Chromosome and chromatid damage
III. Cellular
responses to radiation,
a. Mechanisms of cell
death, b. Cell and
tissue survival assays: measurement of response, c. Models of cell
survival
IV.
Linear energy transfer (LET) and oxygen effect, a. Linear energy transfer, b. Oxygen Effect
V. Tumor biology and
microenvironment, a. Solid tumor assay
systems, b. Tumor
microenvironment
VI. Cancer biology,
a. Cell and tissue
kinetics, b. Molecular
signaling, c.
Mechanisms of cancer development, d. Cancer genetics/genomics
VII. Radiobiology of normal
tissues, a. Clinically relevant normal
tissue responses to radiation, b. Mechanisms of normal tissue radiation
responses, c. Total
body irradiation
VIII. Dose delivery, a
. Therapeutic ratio, b. Time, dose, and
fractionation, c.
Brachytherapy, d.
Radiobiological aspects of different radiation modalities
IX. Combined
modality therapy, a. Chemotherapeutic agents
and radiation therapy, b. Radiosensitizers, bioreductive drugs, and
radioprotectors, c.
Immune therapeutics,
d.
Hyperthermia X. Late effects
and radiation
protection, a. Radiation carcinogenesis,
b. Heritable effects of
radiation, c. Radiation
effects in the developing embryo, d. Radiation protection
The answer, along with an
explanation and
appropriate references, will
be provided for each question.
Editor-in-
Chief:
Marcelo Vazquez, MD,
PhD
Loma
Linda University, Radiation Medicine
MVazquez@llu.edu
Chief-
Technical Editor:
Siamak Shahabi, PhD
Radiation & Cancer Biology Practice Examination,
USA
Rabex
Organization & Advanced Medical Publishing, Inc., USA
info@rabex.net
Contributors:
Marcelo
Vazquez,
MD,
PhD,
Lead,
Clinical
Translational Radiobiology Research Dept. of Radiation
Medicine Loma
Linda University Medical Center, CA,
Alejandro Carabe-Fernandez, PhD,
Department of
Radiation Oncology,
The Hospital of the University of Pennsylvania,
Philadelphia, PA,
Erica Bell, PhD,
Radiation
Oncology, Director, Department of Radiation Oncology, Radiation
Oncology Training Program, Ohio State University,
Columbus, OH, Manuela
Buonanno, PhD,
Columbia University,
Center for Radiological Research,
NY, Veljko Grilj, PhD,
RARAF, Nevis Laboratoriese, Columbia University,
NY
,
Jessica Fleming,
PhD,
Department
of
Radiation Oncology at the Ohio State University,
Columbus,
OH, &
Siamak Shahabi, PhD, Chief-Technical Editor, Radiation &
Cancer Biology Practice Examination, Rabex
Organization & Advanced Medical Publishing, Inc., Proton
Therapy, and
Cancer-Matrix Manual, USA.
Past
Contributors:
1995-present J. D. Chapman, PhD
, Editor-in-Chief
Associate
Editors:
Gary Y. Yang,
Kathryn Huber, MD, PhD, Mark Ritter, MD, PhD, Richard Miller, PhD,
Minesh Mehta, MD, Joan
Allalunis-Turner, PhD, Paul C. Billings, PhD, David A. Boothman,
PhD,
J. Martin Brown, PhD, Lawrence R. Coia, MD, William C. Dewey,
PhD, Evan
B. Douple, PhD, Richard P. Hill, PhD, Clifton C. Ling, PhD, Luka
Milas,
PhD, William F. Morgan, PhD, Colin G. Orton, PhD, Mark A. Ritter,
MD,
PhD, Sara Rockwell, Barry S. Rosenstein, PhD, Joseph L.
Roti
Roti, PhD,
Craig W. Stevens, MD, Beverly A. Teicher, PhD, E. Day Werts, PhD,
& H. Rodney Withers, PhD.
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