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 Radiobiology
A1. A new Rabex 2022: Radiation & Cancer Biology Practice Examination examination, Radiation Oncology  
 
Edited by: Marcelo Vazquez, MD, PhD & Siamak Shahabi, PhD 
The Radiation & Cancer Biology Practice Examination (RABEX) concept introduced in 1995 by Advanced Medical Publishing, Inc., USA 
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Exam opens on June 1, 2022



Download Rabex 2022 Registration Form   Email to -----> info@Rabex.net

Rabex table of content and history  

    The purpose of RABEX: The Radiation and Cancer Biology Practice Examination is to supplement the training of radiation oncology residents by providing an educational resource to help guide residents in the study of cancer and radiation biology. It is anticipated that the  Radiation and Cancer Biology Practice Examination  will also assist residents and board eligible radiation oncologists in preparation for the  Radiation and Cancer Biology  section of the cognitive exam administered by the American Board of Radiology (ABR) for certification in radiation oncology. 

    Well into its second decade of existence, RABEX continues to be a unique and important educational tool for the certification and continuous education of residents and senior radiation oncologists. The present edition of RABEX follows the original goals defined in the 1990's by Drs. J. D. Chapman, S. Shahabi, L. R. Coia and B. Corn. However, due to the increase in knowledge in the field of biology and the rapid development of electronic distribution of information, RABEX needed to be updated to match these challenges. The ultimate goal of the present edition is to maintain its level of excellence with relevant updates in topics and contents.
 
      The topics included in the RABEX practice examination continue to be based upon those listed by the American Board of Radiology for the cognitive exam in radiation and cancer biology. Also, the number of questions in each section reflects the ABR's relative weight for each topic. Therefore, this practice examination provides guidance for residents and senior radiation oncologists in their preparation for the initial radiation oncology certification examination as well as to demonstrate cognitive expertise in radiation biology required for maintenance of certification.

     The exam consists of 200 multiple choice questions in, latest updated ABR Guidelines:

I. Interaction of radiation with matter, a. Definition of ionizing radiation, free radicals, and radical damage, b. Direct and indirect action of radiation,
                                                               numbers and types of DNA lesions, c. Consequences of unrepaired DNA DSB

II. Molecular and cellular damage and repair, a. Molecular mechanisms of DNA damage, b. Molecular mechanisms of DNA repair, c. Cellular recovery,
                                                                        d. Chromosome and chromatid damage

III. Cellular responses to radiation, a. Mechanisms of cell death, b. Cell and tissue survival assays: measurement of response, c. Models of cell survival

IV. Linear energy transfer (LET) and oxygen effect, a. Linear energy transfer, b. Oxygen Effect

V. Tumor biology and microenvironment, a. Solid tumor assay systems, b. Tumor microenvironment

VI. Cancer biology, a. Cell and tissue kinetics, b. Molecular signaling, c. Mechanisms of cancer development, d. Cancer genetics/genomics

VII. Radiobiology of normal tissues, a. Clinically relevant normal tissue responses to radiation, b. Mechanisms of normal tissue radiation responses, c. Total body irradiation

VIII. Dose delivery,
a . Therapeutic ratio, b. Time, dose, and fractionation, c. Brachytherapy, d. Radiobiological aspects of different radiation modalities

IX. Combined modality therapy, a. Chemotherapeutic agents and radiation therapy, b. Radiosensitizers, bioreductive drugs, and radioprotectors, c. Immune therapeutics, 
                                              d. Hyperthermia

X. Late effects and radiation protection, a. Radiation carcinogenesis, b. Heritable effects of radiation, c. Radiation effects in the developing embryo, d. Radiation protection
 
      The answer, along with an explanation and appropriate references, will be provided for each question.

Editor-in- Chief:
Marcelo Vazquez, MD, PhD
Loma Linda University, Radiation Medicine
MVazquez@llu.edu


Chief- Technical Editor:
Siamak Shahabi, PhD
Radiation & Cancer Biology Practice Examination, USA
Rabex Organization & Advanced Medical Publishing, Inc., USA
info@rabex.net


Contributors:

Marcelo Vazquez, MD PhD, Lead, Clinical Translational Radiobiology Research  Dept. of Radiation Medicine  Loma Linda University Medical Center, CA, Alejandro Carabe-Fernandez, PhD, Department of Radiation Oncology, The Hospital of the University of Pennsylvania, Philadelphia, PA, Erica Bell, PhD, Department of Radiation Oncology, Associate professor, Radiation Biology Director, The Ohio State University, Columbus, OH, Manuela Buonanno, PhD, Columbia University, Center for Radiological Research, NY, Veljko Grilj, PhD, RARAF, Nevis Laboratoriese, Columbia University, NY, Jessica Fleming, PhD, Department of Radiation Oncology at the Ohio State University , Columbus, OH, & Siamak Shahabi, PhD, Chief-Technical Editor, Radiation & Cancer Biology Practice Examination, Rabex Organization & Advanced Medical Publishing, Inc., Proton Therapy, and Cancer-Matrix Manual, USA.

Past Contributors: 1995-present
J. D. Chapman, PhD , Editor-in-Chief

Associate Editors:

Gary Y. Yang, Kathryn Huber, MD, PhD, Mark Ritter, MD, PhD, Richard Miller, PhD, Minesh Mehta, MD, Joan Allalunis-Turner, PhD, Paul C. Billings, PhD, David A. Boothman, PhD, J. Martin Brown, PhD, Lawrence R. Coia, MD, William C. Dewey, PhD, Evan B. Douple, PhD, Richard P. Hill, PhD, Clifton C. Ling, PhD, Luka Milas, PhD, William F. Morgan, PhD, Colin G. Orton, PhD, Mark A. Ritter, MD, PhD, Sara Rockwell, Barry S. Rosenstein, PhD, Joseph L. Roti Roti, PhD, Craig W. Stevens, MD, Beverly A. Teicher, PhD, E. Day Werts, PhD, & H. Rodney Withers, PhD.

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             The viewers & users should honor the intellectual property & copyright with inclusion of the architect of  online exam style and score analysis in numerical and graphical configuration. No part of the exam, Questions & Answers should be utilized as a substitute or exploited for internal institution's teaching colloquium and reviewing material in field of Radiation and Cancer Biology without written permission form the Advanced Medical Publishing, AMP,  Rabex, &  Onconet, USA.
 

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   Rabex Copyright  2022, Rabex, Inc., USA


Edited by: Marcelo Vazquez, MD, PhD & Siamak Shahabi, PhD
June 1, 2022
$275.00 U.S. (Shipping Included)
Advanced Medical Publishing, Inc.  ISBN: AMP. Rabex. USA  
email: info@rabex.net
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