Description:
Endothelial cells are early targets of radiation injury.
Because these cells are tissues easily damaged by
radiation, if we can understand the causes of radiation
injury, then normal cells can be well protected and
tumors can be destroyed. The Radiation Biology of the
Vascular Endothelium brings together expert reviews on
the biology and radiobiology of the vasculature, with
emphasis on the endothelial cell component of blood
vessels. The book covers both the basic aspects of
endothelial cell biology and the practical consequences
of this for the oncologist, with special reference to
the radiation oncologist. After reading The Radiation
Biology of the Vascular Endothelium, no clinical or
experimental oncologist should be able to ignore the
intimate relationship between tumor and normal tissue
cells and endothelial cells that form the barrier to,
and are the bearers of, essential nutrient supplies.
Features:
Considers a range of
techniques for assessing endothelial cell function,
viability, and integrity
Provides an understanding of the pathways of
radiation injury in endothelial cells
Contains new data important to both clinical and
experimental researchers working in oncology and related
fields
Offers the expertise of biologists from widely
differing backgrounds, giving the reader a comprehensive
view of endothelial biology and radioresponsiveness
Table of Contents:
Foreword, J. Denekamp
The Endothelial Cell is a Unique Target of Radiation:
An Overview, L.F. Fajardo
The Histopathology of Irradiated Endothelium, D.B.
Rubin and M.L. Griem
Functional Measures of Endothelial Integrity and
Pharmacologic Modification of Radiation Injury, M.M.
Graham and L.M. Peterson
Antioxidant Defenses and the Irradiated Endothelium,
D.B. Rubin, E.A. Drab, and E.R. Blazek
Protein Synthesis in Irradiated Endothelial Cells,
E.M. Rosen and I.D. Goldberg
Signaling in the Radiation Response of Endothelial
Cells, A. Haimovitz-Friedman and Z. Fuks
Effect of Ionizing Radiation on Endothelial Cell
Plasma Membrane Processes, L. Kwock, A.W. Blackstock,
and M. Friedman
Inflammatory Cytokines, Radiation, and Endothelial
Gene Products: A Common Role for Reactive Oxygen
Intermediates, J.C. Murray
Extracellular Matrix Regulates Endothelial Cell
Morphology, Receptor Expression, and Response to Low
Dose Radiation, J.M. Onoda, S.S. Kantak, and C.A.
Diglio
Endothelial-Oriented Strategies to Spare Normal
Tissues, W.F. Ward, A Molteni, and C.-H. Ts'ao
Tumor Bed Phenomenon: Effect on Tumor Progression and
Therapy, L. Milas and M. Milas
Photodynamic Therapy and Endothelial Cells, D.C. West
and J.V. Moore
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