oncologists, surgeons, and scientists comprehensively
review the techniques,
indications, and results of using intraoperative
electrons (IOERT) and
high-dose rate brachytherapy (HDR-IORT).
State-of-the-art topics range from
methods and techniques of treatment and issues of normal
to IORT, to techniques and results by disease-site, as
well as future
possibilities. The disease-site chapters cover everybody
part for which the
potential merit of IORT has been demonstrated, with
factors presented by a radiation oncologist and a
surgeon. The diseases range
from GI cancers to CNS and breast malignancies.
International in authorship and
comprehensive in scope, Intraoperative Irradiation:
Techniques and Results
offers a cutting-edge resource and reference for
oncologists, physicists, anesthesiologists, medical
oncologists, and all others
involved in providing
IORT and HDR-IORT procedures and cancer care today.
“. . .
chapters are very well
written in a concise manner and include excellent
bibliographies. . .a
thorough, well written, informative textbook which would
be a welcome addition
to the radiation and surgical oncologist's reference
“—Doody’s Health Sciences Book Review
comprehensive review by internationallyrecognized
surgeons and scientists likely represents the definitive
text on intraoperative
irradiation and allied techniques…a useful
reference for the dedicated
multidisciplinary oncology team, wishing to have a
comprehensive review of
these techniques (and current results)…The
biophysics of a single high
dose versus multiple small doses is well covered in this
Journal of Surgery “…an appropriate resource
and reference book. It
is intended for surgeons, radiation oncologists,
medical oncologists, and all others involved either in
the procedural component
of IORT or in the care of patients with
Rationale and Historical Perspective. General Rationale
Perspective of Intraoperative Irradiation,Leonard L.
Gunderson, Felipe A.
Calvo, Christopher G. Willett, Louis B. Harrison, and
Manuel Santos. Biology of
Large Dose per Fraction Radiation Therapy,Paul Okunieff,
and Yuhchyaw Chen.
II. Methods and
Techniques of Treatment. Physical Aspects of
Irradiation, Edwin C. McCullough and Peter J. Biggs.
IOERT Treatment Factors:
Technique and Equipment, Christopher G. Willett, Leonard
L. Gunderson, Paul M.
Busse, David Nagorney, Joel E. Tepper, and Felipe A.
Calvo. Physics of
Intraoperative High-Dose-Rate Brachytherapy,Lowell L.
Anderson, Patrick J.
Harrington, and Jean St. Germain. High-Dose-Rate
(HDR-IORT): Technical Factors, Louis B. Harrison, Alfred
M. Cohen, and Warren
Intraoperative Irradiation with
Electron-Beam or High-Dose-Rate Brachytherapy:
Subir Nag, Leonard L. Gunderson, Christopher G. Willett,
Louis B. Harrison, and
Felipe A. Calvo. Part III. Normal Tissue
Tolerance--IORT. Normal Tissue
Tolerance to Intraoperative Irradiation: The National
Cancer Institute Experimental
Studies,William F. Sindelar, Peter A. S. Johnstone,
Harald J. Hoekstra, and
Timothy J. Kinsella. Studies at Colorado State
University of Normal Tissue
Tolerance of Beagles to IOERT, EBRT, or a
Combination,Edward L. Gillette,
Sharon M. Gillette, and Barbara E. Powers. Peripheral
Experimental and Clinical, Edward Gillette, Barbara E.
Powers, Sharon M.
Gillette,Leonard L. Gunderson, and Christopher G.
Willett. Part IV. Results of
IORT With or Without EBRT by Disease Site. Gastric IORT
With or Without
EBRT,Rafael Martinez-Monge, Jean P. Gerard, H. J.
Kramling, F. Guillemin, and
Felipe A. Calvo. IORT in Pancreatic Carcinoma,Paula M.
Termuhlen, Douglas B.
Evans, and Christopher G. Willett. Biliary Tract IORT:
Bile Duct and Gallbladder,Takeshi
Todoroki, Leonard L. Gunderson, and David Nagorney.
Primary Colorectal EBRT and
IOERT,Christopher G. Willett, Paul C. Shellito, and
Leonard L. Gunderson.
Recurrent Colorectal: EBRT With or Without IOERT or
HDR-IORT, Leonard L.
Gunderson, Christopher G. Willett, Michael G. Haddock,
Heidi Nelson, Ignacio
Azinovic, Subir Nag, Felipe A. Calvo, Kjell M. Tviet,
Ralph Dobelbower, and
Hollis W. Merrick. HDR-IORT for Colorectal Cancer:
Clinical Experience, Louis
Bruce D. Minsky, Carol
White, Alfred M. Cohen, and Warren E. Enker. Radiation
Ablation of Liver
Metastases: HDR-IORT With or Without EBRT,Catherine L.
Salem and Anatoly
Dritschilo. Electron or Orthovoltage IORT for
L. Gieschen, Christopher G. Willett, John Donohue, Ivy
Ira J. Spiro,
Felipe A. Calvo, and
Leonard L. Gunderson. HDR-IORT for Retroperitoneal
Sarcomas,Louis B. Harrison,
Lowell Anderson, Carol White, and Murray F. Brennan.
Trunk Soft Tissue
Sarcomas: EBRT With or Without IORT ,Ivy A. Petersen,
Felipe A. Calvo, Leonard
L. Gunderson, Douglas J. Pritchard, Ignacio Azinovic,
Michael G. Haddock, and
Michael Eble. IORT for Bone Sarcomas,Felipe A. Calvo,
Norman Willich, Santiago Amillo, and José
Primary and Recurrent Gynecologic
Malignancies: EBRT With or
Without IOERT or
HDR-IORT, Michael G. Haddock, Rafael
Martinez-Monge, Ivy A.
Timothy O. Wilson.
Genitourinary IORT,Felipe A. Calvo, Horst Zincke,
Leonard L. Gunderson, Javier
Aristu, Jean P. Gerard, Jose M. Berian, and William U.
Shipley. Lung Cancer:
EBRT With or Without IORT, Javier Aristu, Felipe A.
Martínez, Jean Bernard Dubois, Manuel Santos,
Scott Fisher, and Ignacio
Azinovic. Pediatric Malignancies: IORT Alone or With
EBRT, Paula J. Schomberg,
Thomas E. Merchant, Gerald Haase, and Javier Aristu.
IORT for Head and Neck
Cancer,Robert L. Foote, Peter Garrett, William Rate,
Subir Nag, Rafael
Martinez-Monge, Thierry Schmitt, and Thomas V.
McCaffrey. IORT for CNS
Tumors,D. Ortiz de Urbina, N. Willich, R. R. Dobelbower,
J. Aristu, J. C.
Bustos, D. Carter, S. Palkovic, M. Santos, and F. A.
Calvo. IORT for Breast
Cancer, Joyce A. Battle, Jean-Bernard DuBois, Hollis W.
Merrick, and Ralph R.
Dobelbower, J. Aristu, J. C. Bustos, D. Carter, S.
Palkovic, M. Santos, and F.
A. Calvo. IORT for Breast Cancer, Joyce A. Battle,
Jean-Bernard DuBois, Hollis
W. Merrick, and Ralph R. Dobelbower, Jr. Part V.
Conclusions and Future Possibilities.
Conclusions and Future