Exam
opens on June 1,
2023
Rabex table of content and
history
The
purpose of
RABEX:
The
Radiation and Cancer
Biology Practice Examination is to supplement the
training
of radiation oncology residents by providing an
educational resource to help guide residents in the study
of
cancer
and radiation
biology. It is anticipated that the
Radiation and Cancer Biology Practice Examination
will also assist residents and board eligible
radiation
oncologists in preparation for the
Radiation and Cancer Biology
section of
the cognitive
exam
administered by the
American
Board of
Radiology
(ABR)
for certification in radiation oncology.
Well into its
second
decade of existence, RABEX continues to be a unique and
important educational
tool for the certification and continuous education of
residents and
senior radiation oncologists. The
present edition of RABEX
follows
the original goals defined in
the 1990's by Drs. J. D. Chapman, S.
Shahabi, L. R. Coia and B. Corn. However, due to
the
increase in knowledge in the field of biology and
the rapid development of electronic distribution of
information,
RABEX needed to
be updated to match
these challenges. The ultimate goal of the present edition
is to
maintain its level of excellence with
relevant updates in topics and contents.
The topics included in the
RABEX practice
examination continue to be
based upon those listed by
the American Board of Radiology for the
cognitive
exam in
radiation
and cancer biology. Also, the number
of questions in each section reflects the ABR's relative
weight for
each topic. Therefore, this practice
examination provides guidance for residents and senior
radiation
oncologists in their preparation for
the initial radiation oncology certification examination
as
well as to
demonstrate cognitive expertise in
radiation biology required for maintenance of
certification.
The exam consists
of 200 multiple
choice questions in, latest updated ABR
Guidelines:
I.
Interaction
of
radiation with matter,
a. Definition
of
ionizing radiation, free radicals, and radical damage,
b. Direct and indirect
action
of radiation,
numbers and
types of DNA lesions, c. Consequences of unrepaired DNA
DSB
II.
Molecular
and
cellular damage and repair, a.
Molecular
mechanisms of DNA damage, b. Molecular mechanisms of DNA repair,
c. Cellular
recovery,
d.
Chromosome and chromatid damage
III.
Cellular
responses to radiation,
a.
Mechanisms of cell
death, b. Cell
and
tissue survival assays: measurement of response, c. Models of cell
survival
IV.
Linear energy transfer (LET) and oxygen effect,
a. Linear energy transfer, b. Oxygen Effect
V. Tumor
biology and
microenvironment, a.
Solid tumor assay
systems, b.
Tumor
microenvironment
VI. Cancer biology,
a. Cell and
tissue
kinetics, b.
Molecular
signaling, c.
Mechanisms of cancer development, d. Cancer genetics/genomics
VII. Radiobiology
of
normal
tissues, a. Clinically relevant
normal
tissue responses to radiation, b. Mechanisms of normal tissue radiation
responses, c.
Total
body irradiation
VIII. Dose delivery, a
. Therapeutic
ratio,
b. Time, dose,
and
fractionation, c.
Brachytherapy, d.
Radiobiological aspects of different radiation
modalities
IX.
Combined
modality therapy,
a.
Chemotherapeutic
agents
and radiation therapy, b. Radiosensitizers, bioreductive drugs,
and
radioprotectors, c.
Immune therapeutics,
d.
Hyperthermia
X. Late
effects
and radiation
protection, a.
Radiation
carcinogenesis,
b. Heritable
effects of
radiation, c.
Radiation
effects in the developing embryo, d. Radiation protection
The answer, along with an
explanation and
appropriate references, will
be provided for each question.
Editor-in-
Chief:
Marcelo Vazquez, MD,
PhD
Loma
Linda University, Radiation Medicine
MVazquez@llu.edu
Chief-
Technical Editor:
Siamak Shahabi, PhD
Radiation & Cancer Biology Practice
Examination,
USA
Rabex
Organization & Advanced Medical Publishing, Inc.,
USA
info@rabex.net
Contributors:
Marcelo
Vazquez,
MD,
PhD,
Lead,
Clinical
Translational Radiobiology Research Dept. of
Radiation
Medicine Loma
Linda University Medical Center, CA,
Alejandro Carabe-Fernandez, PhD,
Department of
Radiation Oncology,
The Hospital of the University of Pennsylvania,
Philadelphia, PA,
Erica Bell, PhD,
Department of
Radiation Oncology, Associate professor, Radiation Biology
Director, The Ohio State University, Columbus, OH, Manuela
Buonanno, PhD,
Columbia University,
Center for Radiological Research,
NY, Veljko Grilj,
PhD,
RARAF, Nevis Laboratoriese, Columbia University,
NY,
Jessica Fleming,
PhD,
Department
of
Radiation Oncology at the Ohio State University
,
Columbus,
OH,
&
Siamak Shahabi, PhD, Chief-Technical Editor,
Radiation
&
Cancer Biology Practice Examination, Rabex
Organization & Advanced Medical Publishing, Inc.,
Proton
Therapy, and
Cancer-Matrix Manual, USA.
Past
Contributors:
1995-present
J. D. Chapman, PhD
,
Editor-in-Chief
Associate
Editors:
Gary
Y.
Yang,
Kathryn Huber, MD, PhD, Mark Ritter, MD, PhD, Richard
Miller, PhD,
Minesh Mehta, MD, Joan
Allalunis-Turner, PhD, Paul C. Billings, PhD, David A.
Boothman,
PhD,
J. Martin Brown, PhD, Lawrence R. Coia, MD, William C.
Dewey,
PhD, Evan
B. Douple, PhD, Richard P. Hill, PhD, Clifton C. Ling,
PhD,
Luka
Milas,
PhD, William F. Morgan, PhD, Colin G. Orton, PhD, Mark A.
Ritter,
MD,
PhD, Sara Rockwell, Barry S. Rosenstein, PhD,
Joseph L.
Roti
Roti, PhD,
Craig W. Stevens, MD, Beverly A. Teicher, PhD, E. Day
Werts, PhD,
& H. Rodney Withers, PhD.
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