Description:
This
book presents the most widely used biophysical
models for
fractionated external beam radiation therapy and
brachytherapy. The main
equations for each model are derived and
presented
together with extensive
clinical examples designed to help show how the models
are used in daily
clinical practice.
Each model is examined, the main critical and weak
points of each model
are discussed, and some of the mathematics behind the
more complicated models
are explained. The book is intended specifically for
actual daily clinical
attention.
This book is highly recommended for residents and other
professionals in
radiation therapy.
Contents include:
PART 1: External Beam
Therapy
Nominal Standard Dose or Ellis Model
Partial Tolerance
Split Course Corrections
Addition of Schedules
CRE Model
Corrections for Gaps in Treatment
The TDF Approach
TDF Applications to Split Course
Further Developments of the Biological Model
Shortcomings and Criticisms of NSD, CRE, and TDF
Models
Other Power Law Models
Gap Correction
Cell-Population-Kinetic Model (Cohen Model)
Single Hit Multitarget Approach
Linear Quadratic Approach
The Linear Quadratic Model
Isoeffect Relations
Practical Use of the L-Q Model
Calculations for Complex Schedules
PART II: Brachytherapy: Brachytherapy: The Dose-
Rate Effect
The NSD Model for Brachytherapy
The CRE Model for Brachytherapy
CRE Equation for Long-lived Radioisotopes
CRE Equation for Short-lived Radioisotopes
Rest Periods and Volume Effects
The TDF Model for Brachytherapy
TDF for Long-lived Radioactive Sources
TDF for Short-lived Radioactive Sources
Teq for Short-lived Sources or Temporary Implants
Teq for Permanent Implants
TDF for Split-course Brachytherapy
Total TDF for Brachytherapy + External Beam
The L-Q Model for Brachytherapy
Temporary Implants
Permanent Implants
Multiple Fractions Per Day With Incomplete Repair
Between Fractions
Appendix A: Summary of Equations of Biological Models
Appendix B: CED and TDF
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