Desription:
Basic Clinical Radiobiology
is a concise but comprehensive textbook
setting out the essentials of the science and clinical
application of radiobiology for those seeking
accreditation in radiation oncology, clinical radiation
physics, and radiation technology.
Fully revised and updated to
keep abreast of current developments in radiation biology
and radiation oncology, this fifth edition continues to
present in an interesting way the biological basis of
radiation therapy, discussing the basic principles and
significant developments that underlie the latest attempts
to improve the radiotherapeutic management of cancer.
This new edition is highly illustrated with
attractive 2-colour presentation and now includes new
chapters on stem cells, tissue response and the
convergence of radiotherapy, radiobiology, and physics. It
will be invaluable for FRCR (clinical oncology) and
equivalent candidates, SpRs (and equivalent) in radiation
oncology, practicing radiation oncologists and
radiotherapists, as well as radiobiologists and
radiotherapy physicists.
Table of Contents:
Introduction: The
significance of radiobiology and radiotherapy for cancer
treatment. Irradiation-induced damage and the DNA damage
response. Cell death after irradiation: How, when and why
cells die. Quantifying cell kill and cell survival.
Radiation dose-response relationships. Linear energy
transfer and relative biological effectiveness. Physics of
radiation therapy for the radiobiologist. Tumour growth
and response to radiation. Fractionation: The linear-
quadratic approach. The linear-quadratic approach in
clinical practice. Modified fractionation. Time factors in
normal tissue responses to irradiation. The dose-rate
effect. Pathogenesis of normal tissue side effects. Stem
cells in radiotherapy. Normal tissue tolerance and the
effect of dose inhomogeneities. The oxygen effect and
therapeutic approaches to tumour hypoxia. The tumour
microenvironment and cellular hypoxia responses. Combined
radiotherapy and chemotherapy. Molecular targeted agents
for enhancing tumour response. Biological
individualisation of radiotherapy. Molecular image guided
radiotherapy. Retreatment tolerance of normal tissues.
Biological response modification of normal tissue
reactions: Basic principles and pitfalls. Hadron therapy:
The clinical aspects. Tissue response models. Second
cancers after radiotherapy.
Editors: Michael Joiner: Professor of Radiobiology, Wayne
State University, USA
Albert van der Kogel: Emeritus Professor of
Radiobiology, Radboud University Nijmegen Medical Centre,
The Netherlands; also Department of Human Oncology,
University of Wisconsin, USA | 
