Description:
A cutting-edge
review of how derangements in the hormonal and growth
factor mechanisms
controlling normal mammary development lead to breast
cancer. Drawing on the
multidisciplinary expertise of leading authorities, the
book highlights the
roles of oncogenes and tumor suppressor genes, spelling
out the importance of
autocrine/paracrine loops (e.g., stromal epithelial
interactions) in supporting
breast cancer cell proliferation and the progression to
hormone independence.
The book’s many prominent contributors also
illuminate significant recent
advances in the biochemistry and physiology of hormone
receptors and review the
state-of –the-art in the endocrine therapy of
breast cancer.
Endocrinology of Breast Cancer provides a unique
integrated overview of the most
significant basic and clinical developments concerning
the hormonal aspects of
breast cancer.
Reviews:
A variety of topics are covered, including
carcinogenesis,
tumor progression,
therapeutic options, and benign breast disease. The
section divisions of the
book make it easy to locate topics of interest. Each
chapter has an extensive
list of references for further study. Parts IV and V are
very thorough in
reviewing targets for therapy and endocrine therapy.
These chapters provide a
good basis from which to understand the development of
endocrine therapies. The
discussion of normal breast physiology and development
is beneficial for the
less specialized physician and helps to round out the
discussion.
“—Doody’s Health Science Book Review
Journal “...an
invaluable resource for both basic scientists and
clinicians who need to update
their knowledge about breast cancer
biology...�—Cell Biology
International 2000
