Description
:
The epidemiological and clinical importance of bone metastasis has
long been recognized, but the past decade has seen an explosion in the
fields of bone biology and bone cancer research. This period of time
has been marked by a number of key discoveries that have led to the
opening up of entirely new areas for investigation as well as new
therapies which combine surgery and biological therapeutic approaches.
Bone is a common site of cancer metastases - cancer cells commonly
develop in bone and spread to other organ systems through the
bloodstream. For example, the incidence of bone metastases in breast
and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic
lung cancer. In clinical terms, bone metastases have substantial
negative effects on a patient's quality of life and are a main cause of
patient mortality. Given the global prevalence of breast and prostate
cancers, knowledge of bone biology has become essential for the medical
and cancer research communities. This book provides, all in one
resource, the most recent data on bone cancer development (cellular and
molecular mechanisms), genomic and proteomic analyses, clinical
analyses (histopathology, imaging, pain monitoring), as well as new
therapeutic approaches and clinical trials for primary bone tumors and
bone metastases.
Written For:
Bone biologists, cancer researchers, oncologists, orthopedic
surgeons, radiologists and other specialists in cancer imaging; Medical
libraries; graduate academic libraries.
Table of contents:
Section 1: Genetic Control, Frequencies and Epidemiology of Bone Caner
1. Epidemiology of Primary Bone Tumors
and Economical Aspects of Bone Metastases
Esther I. Hauben and Pancras C.W. Hogendoorn
Section 2: Bone Microenvironment
and Bone Cancer
2. Tumor-Bone Cell Interactions in Bone Metastases
Pierrick G.J. Fournier, Lauren K. Dunn,
Gregory A. Clines, Theresa A. Guise
3. Early Bone Metastasis-Associated Molecular and Cellular Events
Philippe
Clezardin
4. Regulation of Osteoblast Differentiation and Bone Cancers by Wnt and Parathyroid Hormone Signaling Pathways
Julia Billiard, John A. Robinson, Ramesh A. Bhat, Bheem M. Bhat, Richard Murrills and Peter V.N. Bodine
5. Osteoclast
Differentiation and Function
Luis Filgueira
6. Immunoregulation of Osteoclast Differentiation in Multiple Myeloma
Bone Diseases
Maria Grano, Giacomina Brunetti and Silvia Colucci
7. Facts and Hypothesis on Osteolytic Lesions
Related to Normal and Tumoral Epithelial Dental Cell Differentiation
Blandine Ruhin, Frederic Lezot, Aymann Bouattour, Sonia Ghoul-Mazghar,
Ariane Berdal, Vianney Descroix
8. The Role of the Interleukin-6 Family of Cytokines in Bone Remodeling and Bone Cancer
Frederic Blanchard, Emmanuelle David, B n dicte Brounais
9. Proteases and Therapeutic Approaches of Bone Tumors
Velasco C. Ruiz, Y. Fortun, Dominique Heymann, Marc Padrines
Section 3: and Bone Markers of Cancer (genes and proteins)
10.Bone Remodelling Markers and Bone Cancer
Markus J. Seibel
11. Cytogenetic and Molecular
Genetic Alterations in Bone Tumors
Suvi Savola, Tom B hling, Sakari Knuutila
12. Cytogenetic of Bone Tumors
Jiyun Lee, Mallory Martin, Shibo Li
13. Genetic Aspects of Bone Tumors
Shamini Selvarajah, Maria Zielenska,
Jeremy A. Squire, Paul Park
14. Proteomic of Bone Cancers
Stephanie Byrum, Eric Siegel, Sudeepa Bhattacharyya,
Larry J Suva
15. Gene and proteomic profiling of osteosarcoma
Tsz-Kwong Man, Pulivarthi H. Rao, Ching C. Lau
16. Molecular Pathology of Osteosarcoma
Walter C. eBell, Gene P. Siegal
Sction
4: Histopathology of Primary Bone Tumors and Bone Metastases
17. Technical Aspects: How Do We Best Prepare Bone Samples
for Proper Histological Analysis?
Daniel Chappard
18. Osteoclast-Rich Lesions of Bone: A Clinical and Molecular
Overview
Adrienne Flanagan, Roberto Tirabosco, Panagiotis D. Gikas
19. Recent Advances in Biology of Bone Tumors
and New Diagnostic Tools
Gonzague de Pinieux, Corinne Bouvier
20. Ewing Sarcoma Family of Tumors
Joseph
D. Khoury
21. The Histopathology of Skeletal Metastases
David G. Hicks, Ping Tang
Section 5: Imaging of Bone Cancer
22. Interventional Radiologic Techniques and their Contribution of the Management
of Bone Tumors
Robert G. Jones, Eric J. Heffernan, Faisal Rashid, Peter L. Munk
23. Imaging of Bone Metastases
Nieroshan Rajaurbendra, Nathan Lawrentschuk
24. Diagnosis of Skeletal Metastases in Malignant Extraskeletal Cancers
Holger Schirrmeister, Coskun Arslandemir
Section 6: Pain Control in Bone Cancer
25. Pain Control with Palliative Radiotherapy in Bone Metastases
Alysa Fairchild, Amanda Hird, Edward Chow
26.
Mechanisms and Management of Bone Cancer Pain
Mary Ann C. Sabino, Denis R. Clohisy
27. Malignant Skeletal Pain:
Mechanisms and Potential Therapeutic Opportunities Monica Herrera, Juan Miguel Jimenez-Andrade, Marina Vardanyan,
Patrick Mantyh
Section 8: New Therapeutic Advance in Primary Bone Cancers and Bone Metastases
28.
Animal Models of Malignant Primary Bone Tumors and Novel Therapeutic Approaches
Julie Rousseau, Fran ois Lamoureux, Gaelle Picarda,
Fran ois Gouin, Val rie Trichet, Fran oise R dini
29. In Vivo Models Used in Studies of Bone Metastases
Ingunn
Holen, Michele A. Lawson
30. Cytokine Gene Therapy in Bone Remodeling
Carl Richards, David Smyth
31. Non-Surgical Treatment of Chondrosarcoma: Current Concepts and Future Perspectives
Eric L. Staals, Emanuela Palmerini,
Stefano Ferrari, and Mario Mercuri
32. Mechanistic Role of RANKL in Cancer Induced Bone Diseases and Development of Targeted
Therapy to Inhibit this Pathway
William C. Dougall
33. Chondrosarcoma of Bone: Diagnosis and Therapy
Arne
Steitbueger, Jendrik Hardes, Georg Gosheger
34. Current Status of Immunotherapy for Osteosarcoma and its Future Trends
Kanji Mori, Kosei Ando, Yoshitaka Matsusue, Dominique Heymann
35. Bisphosphonates, Bone Health and the Clinical Biology
of Bone Metastases from Breast Cancer
Alexander Paterson
36. A Multi-Targeted Approach to Treating Bone Metastases
Robert D. Loberg, Kenneth J. Pienta
37. Bone Metasteses of Prostatic Cancer: Pathophysiology, Clinical Complications,
Actual Treatment and Future Directions
Sara De Dosso, Fernanda G. Herrera, Dominik R. Berthold
38. Apoptosis and
Drug Resistance in Malignant Bone Tumors
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