Description:
A comprehensive review of radioisotope-based molecular imaging probes (radiopharmaceuticals) for PET and SPECT
Covers basics of nuclear chemistry, radiochemistry and radiopharmacology
Discusses potential applications in drug development, translational medicine and clinical diagnostics
Presents a synthesis of radiopharmaceuticals, GMPs and regulatory issues
Written by an experienced radiochemist and scientist
Radioisotope-based
molecular imaging probes provide unprecedented insight into
biochemistry and function involved in both normal and disease states of
living systems, with unbiased in vivo measurement of regional
radiotracer activities offering very high specificity and sensitivity.
No other molecular imaging technology including functional magnetic
resonance imaging (fMRI) can provide such high sensitivity and
specificity at a tracer level. The applications of this technology can
be very broad ranging from drug development, pharmacokinetics, clinical
investigations, and finally to routine diagnostics in radiology. The
design and the development of radiopharmaceuticals for molecular
imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique
challenge. This book is intended for a broad audience and written with
the main purpose of educating the reader on various aspects including
potential clinical utility, limitations of drug development, and
regulatory compliance and approvals.
Table of Contents: Molecular imaging: introduction. Science of atomism: a brief history.
Atoms and radiation. Radioactivity. Production of radionuclides. PET
and SPECT scanners. Chemistry: basic principles. Cell and molecular
biology. Radiopharmaceuticals. Chemistry of radiohalogens (F, Br and
I). Chemistry of organic radionuclides (C, N, and O). Chemistry of
metal radionuclides (Rb, Ga, In, Y, Cu and Tc). Quality control of
radiopharmaceuticals. Mechanisms of radiopharmaceutical transport and
localization. Pharmacokinetics and modeling. Molecular imaging in
oncology. Molecular imaging in cardiology. Molecular imaging in
neurology and psychiatry. Molecular imaging of gene expression.
Molecular imaging in drug development. Radiation dosimetry and
protection. Radiopharmaceuticals, GMPs and regulatory issues.
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