The definitive text on Hodgkin lymphoma is now in its thoroughly revised, updated Second Edition. More than 100 recognized authorities from all parts of the world provide comprehensive, current information on every aspect of Hodgkin lymphoma, including etiology, epidemiology, biology, pathology, evaluation, staging, treatment, and follow-up.

This edition describes the increased use of PET scanning in staging and follow-up. Chapters discuss current treatment options—including combination chemotherapy, radiation therapy, novel treatment techniques, and hematopoietic stem cell transplantation—and offer guidelines for treatment selection. Full consideration is given to late effects of therapy and clinical trials for assessing quality of life in patients.

Table of Contents:

HISTORICAL ASPECTS, ETIOLOGY, AND EPIDEMIOLOGY: A Brief Consideration of Thomas Hodgkin and His Times, Samuel Hellman / The Epidemiology of Hodgkin Lymphoma, Nancy E. Mueller, Seymour Grufferman, and Ellen T. Chang / Association of Epstein-Barr Virus with Hodgkin Lymphoma, Richard F. Ambinder, Ruth Jarrett, and Lawrence M. Weiss

BIOLOGY AND PATHOLOGY: Pathology of Hodgkin Lymphoma, Lawrence M. Weiss, Roger A. Warnke, Martin-Leo Hansmann, John K.C. Chan, Hans Konrad Mueller-Hermelink, Nancy Harris, Harald Stein, and Elaine Jaffe / Nature of the Reed-Sternberg Cell, the L&H Cell, and Their Molecular Biology in Hodgkin Lymphoma, Ralf Kuppers and Daniel Re / Cytokines, Cytokine Receptors, and Chemokines in Hodgkin Lymphoma, Ma Yue, Anke van den Berg, Cigdem Atayar, Lydia Visser, and Sibrand Poppema / Dysregulated Immune Response in Hodgkin Lymphoma, Sibrand Poppema / Cytogenetics of Classical Hodgkin Lymphoma, Stefan Joos and Reiner Siebert

STAGING AND INITIAL EVALUATION: Clinical Evaluation and Staging of Hodgkin Lymphoma, David C. Hodgson and Mary K. Gospodarowicz / Anatomic Imaging, Axel Gossman / Functional Imaging in Hodgkin Lymphoma, Sukru Mehmet Erturk, Andrea Ng, and Annick D. Van den Abbeele / Prognostic Factors in Hodgkin Lymphoma, Lena Specht and Dirk Hasenclever

TREATMENT PRINCIPLES AND TECHNIQUES: Principles of Radiation Therapy in Hodgkin Lymphoma, Joachim Yahalom, Richard T. Hoppe, and Peter M. Mauch / Principles of Chemotherapy in Hodgkin Lymphoma, Rachael E. Hough and Barry W. Hancock / Novel Treatment Techniques for Hodgkin Lymphoma, Jan Oliver Staak, Roland Schnell, Peter Borchmann, and Andreas Engert

SELECTION OF TREATMENT: Treatment of Favorable Prognosis, Stage I-II Hodgkin Lymphoma, Peter M. Mauch, Theodore Girinsky, Karolin Behringer, Joseph M. Connors, and Santiago Pavlovsky / Treatment of Unfavorable Prognosis, Stage I-II Hodgkin Lymphoma, Richard T. Hoppe, Andreas Engert, and Evert M. Noordijk / Treatment of Stage III-IV Hodgkin Lymphoma, Volker Diehl, Sandra Horning, and Berthe Aleman / Management of Recurrent Hodgkin Lymphoma, George P. Canellos and Andreas Josting / Role of Hematopoietic Stem Cell Transplantation in Hodgkin Lymphoma, James O. Armitage, Angelo M. Carella, Norbert Schmitz, Armand Keating, and Philip J. Bierman / Pediatric Hodgkin Lymphoma, Melissa M. Hudson, Dieter Korholz, and Sarah S. DonaldsonLucia Nogova, Jeremy Franklin, Volker Diehl, and Andreas Engert / Clinical Presentation and Treatment of Lymphocyte Predominant Hodgkin Lymphoma,

LATE EFFECTS: Life Expectancy in Hodgkin Lymphoma, Andrea Ng, Peter M. Mauch, and Richard T. Hoppe / Second Cancers after Treatment of Hodgkin Lymphoma, Flora E. Van Leeuwen, Anthony J. Swerdlow, and Lois B. Travis / Cardiovascular Late Effects after Treatment of Hodgkin Lymphoma, Steven L. Hancock / Other Complications of the Treatment of Hodgkin Lymphoma, Julie M. Vose, Louis S. Constine, and Simon B. Sutcliffe / Assessing the Quality of Life in Patients with Hodgkin Lymphoma: Instruments and Clinical Trials, Henning Flechtner, Michel Henry-Amar, Patricia Fobair, Florence Joly, and Jens-Ulrich Rueffer